Latent Osteomalacia in Epileptic Patients on Anticonvulsants

Preliminary study on the efficacy and tolerability of newer anticonvulsants in a population of epileptic patients.

OBJECTIVE To study the efficacy and safety of newer antiepileptic drugs. SUBJECTS AND METHODS Clinical records of 461 epileptic patients attending the Consorcio General Hospital, Valencia, Spain, were reviewed. Demographic data, adverse reactions and clinical outcome were recorded. RESULTS One hundred and five patients experienced a total of 151 adverse drug reactions to antiepileptic medic...

Effect of vitamin D on bone mineral mass in normal subjects and in epileptic patients on anticonvulsants: a controlled therapeutic trial.

The bone mineral mass was estimated by photon absorptiometry in 23 epileptic patients on long-term treatment with phenytoin and in 20 normal subjects before and during treatment with vitamin D or placebo.Initially, subnormal values of bone mineral mass were found in the epileptic patients. The group of epileptic patients treated with vitamin D showed a significant increase in bone mineral mass....

Phenytoin induced severe disabling osteomalacia in a young male with seizure disorder.

While the use of anti epileptic drugs (AEDs) for a long period is a known risk factor for bone loss and pathological fractures, yet the physicians are not yet sensitized to this possibility. It is now believed that the patients who have fractures due to long-term treatment with anticonvulsants have osteomalacia as the predominant lesion. This has been attributed to the alterations in the levels...

Serum levels of zinc and copper in epileptic children during long-term therapy with anticonvulsants

OBJECTIVE To evaluate the serum levels of zinc and copper in epileptic children during the long-term treatment of anticonvulsant drugs and correlate this with healthy subjects. METHODS A hospital-based group matched case-control study was conducted in the Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt between November 2013 and October 2014. Ninety patients a...

Strontium and osteomalacia in renal failure patients.